Created and written by Robert and Michelle King, The Second Wave follows an unexpected, deadly second wave of the coronavirus outbreak in New York City. It follows the lives of two neighbors, Rachel (McDonald) and Lily (Schilling), as they navigate life in quarantine in New York City. While Rachel juggles her many telemedicine clients as well as a shaky, passionless marriage, Lily is upstairs just trying to convince her Wall Street clientele that her very specific skillset is still just as valuable over video as it was in person.